aking frequent painkillers whereas on the capsule could result in a small elevated threat of blood clots, analysis suggests.
Consultants stated that whereas the chance is low, girls needs to be knowledgeable of the hyperlink between non-steroidal anti-inflammatory medication (NSAIDs) and hormonal contraception.
NSAIDs are broadly used to alleviate ache, fever and to scale back irritation.
The principle varieties of NSAIDs within the UK embrace ibuprofen, naproxen, diclofenac, celecoxib, mefenamic acid, etoricoxib and indomethacin.
The Danish research, printed within the British Medical Journal (BMJ), included information for greater than two million girls.
It discovered that the chance was larger in girls utilizing ibuprofen, diclofenac and naproxen whereas on mixed drugs containing progesterone and oestrogen, however was smaller in girls utilizing progestogen-only drugs (typically known as the mini-pill), implants and coils.
The researchers used nationwide medical data to trace diagnoses of venous thromboembolism (blood clots) amongst two million girls aged 15 to 49 dwelling in Denmark between 1996 and 2017 with no historical past of blood clots, most cancers, hysterectomy or fertility remedy.
Hormonal contraception was divided into excessive, medium and low threat, based on their hyperlinks with clots in earlier research.
The researchers stated excessive threat, hormonal contraception included mixed drugs containing both 50mcg oestrogen or third or fourth technology progestogen, whereas medium threat included all different mixed oral contraceptives.
Low or no threat included the mini capsule, implants and coils.
The research discovered that NSAIDs had been utilized by 529,704 girls on hormonal contraception, with ibuprofen being essentially the most incessantly used NSAID (60%), adopted by diclofenac (20%) and naproxen (6%).
Over a median of 10 years, 8,710 venous clots occurred (2,715 pulmonary embolisms and 5,995 deep venous thromboses), and 228 (2.6%) girls died inside 30 days of analysis.
The research discovered NSAID use was related to 4 further venous thromboembolic occasions per week per 100,000 girls not utilizing hormonal contraception, 11 further occasions in girls utilizing medium threat hormonal contraception, and 23 further in girls utilizing excessive threat hormonal contraception.
The hyperlink was strongest for diclofenac in contrast with ibuprofen and naproxen, the paper discovered.
The specialists warned the research didn’t show a hyperlink however stated girls needs to be given details about the dangers.
They stated: “Girls needing each hormonal contraception and common use of NSAIDs needs to be suggested accordingly.”
A spread of things that might affect the outcomes, similar to age, schooling stage, being pregnant historical past, prior surgical procedure, hypertension and diabetes, had been taken into consideration when analysing the findings.
Dr Channa Jayasena, medical senior lecturer and marketing consultant in reproductive endocrinology and andrology, Imperial School London, stated: “Blood clots are harmful since they’ll lodge within the lungs inflicting respiratory and coronary heart issues.
“Contraceptive drugs and painkillers like ibuprofen are important for a lot of girls to keep away from being pregnant and address interval ache.
“Painkillers and the capsule (like all medication) can often trigger critical side-effects.
“However I don’t suppose this research alone ought to postpone girls taking both the capsule, painkillers, or each if wanted.
“An important message needs to be for all girls to scale back blood clot threat by smoking cessation and weight reduction.”
Supply hyperlink
