Officers had been referred to as to stories of a stabbing in Woodman Avenue, close to the Royal Docks in Newham, simply earlier than 7pm on Friday.
The teenage sufferer was pronounced useless on the scene.
Detective Superintendent Paul Whiteman, Head of CID for the North East BCU, stated: “I’m shocked at this tragic lack of a younger life.
“An arrest has been made however the investigation remains to be in its early levels. I might enchantment to any members of the area people to return ahead with any info which could assist carry these accountable to justice.
“Native officers will step up patrols within the space within the coming days to reassure the general public and proceed to focus on violent crime.”
The investigation is being led by the Met’s Specialist Crime Command (Murder). Anybody with info is urged to name the incident room on 0208 345 3715.
Alternatively, they’ll contact the impartial charity Crimestoppers, anonymously, on 0800 555 111.