COVID-19 Vaccine Effectiveness

What CDC is doing

Outcomes of vaccine effectiveness research are vital to CDC’s vaccine program and nationwide vaccine coverage decision-making.

The general objective of CDC’s vaccine effectiveness program is to generate the excellent proof wanted to tell COVID-19 vaccine coverage selections and CDC steerage on different prevention measures.

To perform this, CDC in collaboration with public well being and educational companions, conducts observational research to guage the real-world effectiveness of licensed and licensed COVID-19 vaccines in the US.

These research generate information on how nicely vaccines work in keeping with:

• Age group (for instance, younger youngsters, adolescents, adults, and adults ages 65 and older)

• Danger group (for instance, individuals with underlying well being situations and pregnant ladies)

• Danger setting (for instance, residents of long-term care amenities and healthcare employees)

• End result (for instance, towards extreme outcomes, corresponding to hospitalization or dying; and milder outcomes, corresponding to symptomatic an infection)

• Vaccine product (for instance, unique monovalent, bivalent, or up to date [2023-24] monovalent)

• Vaccine dose (for instance, major collection, extra doses, time since final dose)

CDC is dedicated to routinely evaluating vaccine effectiveness to detect adjustments that may very well be attributable to:

• Waning of vaccine safety

This work helps CDC establish inhabitants subgroups who could profit from extra doses sooner or later.

Updates summarizing the outcomes of CDC led vaccine effectiveness evaluations are offered on COVID Knowledge Tracker.

Guiding ideas for monitoring vaccine effectiveness

The targets of CDC’s COVID-19 vaccine effectiveness program are to guage present COVID-19 vaccines and inform selections by the U.S. Advisory Committee on Immunization Practices relating to COVID-19 vaccine coverage. CDC accomplishes these targets by:

• Assessing COVID-19 vaccine effectiveness in key populations and towards key outcomes (see beneath)

• Offering well timed information to guage effectiveness of recent vaccine suggestions

• Detecting adjustments in COVID-19 vaccine effectiveness attributable to waning of vaccine-induced safety and emergence of recent variants

• Together with populations at excessive danger for extreme COVID-19

• Speaking findings to coverage makers, the scientific group, the general public, and different stakeholders