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Coronavirus Illness 2019 (COVID-19)

An infection prevention and management issues for residents of long-term care services with systemic indicators and signs following COVID-19 vaccination

Observe: Methods are wanted by long-term care services to appropriately consider and handle post-vaccination indicators and signs amongst their residents.  The strategy described on this doc is meant to stability:

  • the chance of pointless testing and implementation of Transmission-Primarily based Precautions for residents with solely post-vaccination indicators and signs with that of
  • inadvertently permitting residents with infectious COVID-19 or one other transmissible infectious illness to show others within the facility.

Whereas this steering is meant for long-term care services, it may be utilized to sufferers in different healthcare settings.  These issues are primarily based on the present understanding of indicators and signs following COVID-19 vaccination, together with timing and period, and would possibly change as expertise with the vaccine accumulates.


Systemic indicators and signs, similar to fever, fatigue, headache, chills, myalgia, and arthralgia, can happen following COVID-19 vaccination. Preliminary knowledgeexterior icon from mRNA COVID-19 vaccine trials point out that almost all systemic post-vaccination indicators and signs are delicate to average in severity, happen throughout the first three days of vaccination (the day of vaccination and following two days, with most occurring the day after vaccination), resolve inside 1-2 days of onset, and are extra frequent and extreme following the second dose and amongst youthful individuals in comparison with those that are older (>55 years). Cough, shortness of breath, rhinorrhea, sore throat, or lack of style or odor are usually not according to post-vaccination signs, and as an alternative could also be signs of SARS-CoV-2 or one other an infection.

Observe: The next indicators and signs, alone, are not according to SARS-CoV-2 an infection and ought to be managed per typical protocols for vaccine-related uncomfortable side effects:

  • rapid hypersensitivity reactions (e.g., urticaria, anaphylaxis)
  • native signs (e.g., ache, swelling, or redness at injection website)

Routine an infection prevention and management practices:

Healthcare personnel at long-term care services ought to comply with the really helpful an infection prevention and management practices described within the Making ready for COVID-19 in Nursing Houses and the Interim An infection Prevention and Management Suggestions for Healthcare Personnel Through the Coronavirus Illness 2019 (COVID-19) Pandemic.  These suggestions, which emphasize shut monitoring of residents of long-term care services for signs of COVID-19, common supply management, bodily distancing (when doable), hand hygiene, and optimizing engineering controls, are meant to guard healthcare personnel and residents from exposures to SARS-CoV-2.  Use of private protecting gear (PPE), together with common use of a facemask and eye safety for healthcare personnel in areas experiencing average to substantial group transmission who’re caring for residents not suspected to have SARS-CoV-2 an infection, can also be really helpful.

As a result of info is presently missing on vaccine effectiveness within the normal inhabitants; the resultant discount in illness, severity, or transmission; or the period of safety, residents and healthcare personnel ought to proceed to comply with all present an infection prevention and management suggestions to guard themselves and others from SARS-CoV-2 an infection, no matter their vaccination standing.

Steered approaches to evaluating and managing systemic new onset post-vaccination indicators and signs for residents in long-term care services.

The approaches described within the Desk under apply to residents who’ve acquired COVID-19 vaccination within the prior 3 days (together with day of vaccination, which is taken into account day 1).

All symptomatic residents ought to be assessed; the approaches recommended within the desk under ought to be tailor-made to suit the scientific and epidemiologic traits of the precise case.

In any scenario, optimistic viral (nucleic acid or antigen) assessments for SARS-CoV-2, if carried out, ought to not be attributed to the COVID-19 vaccine, as vaccination doesn’t affect the outcomes of those assessments.

Indicators and Signs with Steered strategy
Indicators and Signs Steered strategy Further notes
Indicators and signs unlikely to be from COVID-19 vaccination:

Presence of ANY systemic indicators and signs according to SARS-CoV-2 (e.g., cough, shortness of breath, rhinorrhea, sore throat, lack of style or odor) or one other infectious etiology (e.g., influenza) which are not typical for post-vaccination indicators and signs

Consider for doable infectious etiologies, together with testing for SARS-CoV-2 and/or different pathogens, as applicable.

Pending analysis, these residents ought to be positioned in a single particular person room (if obtainable) and cared for by healthcare personnel sporting all PPE really helpful for residents with suspected or confirmed SARS-CoV-2 an infection.  They need to not be cohorted with residents with confirmed SARS-CoV-2 an infection until they’re additionally confirmed to have SARS-CoV-2 an infection by way of testing.

Standards for when Transmission-Primarily based Precautions could also be discontinued depend upon the outcomes of the analysis.

If carried out, a damaging SARS-CoV-2 antigen check in a resident who has indicators and signs that aren’t typical for post-vaccination indicators and signs ought to be confirmed by SARS-CoV-2 nucleic acid amplification check (NAAT). Additional info on testing is accessible right here:
Indicators and signs which will be from both COVID-19 vaccination, SARS-CoV-2 an infection, or one other an infection:

Presence of ANY systemic indicators and signs (e.g., fever, fatigue, headache, chills, myalgia, arthralgia) which are according to post-vaccination indicators and signs, SARS-CoV-2 an infection, or one other infectious etiology (e.g., influenza).
Fever in long-term care settings is outlined as a single measured temperature of 100.0oF (37.8oC) or increased or repeated temperatures of 99.0oF (37.2oC).

Consider the resident.

These residents ought to be restricted to their present room (apart from medically obligatory procedures) and intently monitored till:

  • Fever (if current) resolves and
  • Signs enhance

Healthcare personnel caring for these residents ought to, ideally, put on all PPE really helpful for residents with suspected or confirmed SARS-CoV-2 an infection whereas evaluating the reason for these signs.  Methods to optimize PPE provide can be found right here: https://www.cdc.gov/coronavirus/2019-ncov/hcp/ppe-strategy/index.html

If the resident’s signs resolve inside 2 days, precautions might be discontinued. Fever, if current, ought to have resolved for at the least 24 hours earlier than discontinuing precautions.

Viral testing for SARS-CoV-2 ought to be thought-about for residents if their signs are usually not enhancing or persist for longer than 2 days.
Residents residing in services with energetic transmission, or who’ve had extended shut contact with somebody with SARS-CoV-2 an infection within the prior 14 days, ought to be examined for SARS-CoV-2 an infection.

If SARS-CoV-2 antigen testing is used to guage a symptomatic resident, a damaging antigen check in a resident who has signs which are restricted solely to these noticed following COVID-19 vaccination (i.e., don’t have cough, shortness of breath, rhinorrhea, sore throat, or lack of  style or odor) might not require confirmatory SARS-CoV-2 NAAT.

Nonetheless, confirmatory SARS-CoV-2 NAAT testing ought to be performed if there’s energetic transmission within the facility, if the resident has had extended shut contact with somebody with SARS-CoV-2 an infection within the prior 14 days, or if signs persist for longer than 2 days.

Further info is accessible right here: https://www.cdc.gov/coronavirus/2019-ncov/lab/assets/antigen-tests-guidelines.html

Further Assets:

An infection prevention and management issues for healthcare personnel with systemic indicators and signs following COVID-19 vaccination might be discovered at: https://www.cdc.gov/coronavirus/2019-ncov/hcp/post-vaccine-considerations-healthcare-personnel.html

Further info on COVID-19 vaccines and suggestions:



Antagonistic occasions that happen in a recipient following COVID-19 vaccination ought to be reported to VAERS. Vaccination suppliers are required by the Meals and Drug Administration to report vaccination administration errors, severe adversarial occasions, instances of Multisystem Inflammatory Syndrome, and instances of COVID-19 that end in hospitalization or loss of life following COVID-19 vaccination underneath Emergency Use Authorization. Reporting is inspired for some other clinically vital adversarial occasion even whether it is unsure whether or not the vaccine induced the occasion. Data on find out how to submit a report back to VAERS is accessible at https://vaers.hhs.govexterior icon or by calling 1-800-822-7967.


Critical adversarial occasion: Critical adversarial occasions are outlined as loss of life; a life-threatening adversarial occasion; inpatient hospitalization or prolongation of present hospitalization; a persistent or vital incapacity or substantial disruption of the power to conduct regular life features; a congenital anomaly/delivery defect; an necessary medical occasion that primarily based on applicable medical judgement might jeopardize the person and will require medical or surgical intervention to stop one of many outcomes listed on this definition.

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